Organized at Belleville, Ill., and mustered in June 25, 1861. Moved to Bird's Point, Mo., July 11, 1861. Attached to District of Cairo to October, 1861. 2nd Brigade, District of Cairo, to February, 1862. 4th Brigade, 1st Division, District of Cairo, February, 1862. 2nd Brigade, 4th Division, Army of the Mississippi, to April, 1862. 1st Brigade, 1st Division, Army of the Mississippi, to September, 1862. 1st Brigade, 13th Division, Army of the Ohio, to November, 1862. 3rd Brigade, 3rd Division, Right Wing 14th Army Corps, Army of the Cumberland, to January, 1863. 3rd Brigade, 3rd Division, 20th Army Corps, Army of the Cumberland, to October, 1863. 3rd Brigade, 2nd Division, 4th Army Corps, to July, 1864.
SERVICE - Duty at Bird's Point, Mo., till February, 1862. Charlestown-Bird's Point August 19-20, 1861 (Cos. "A," "B," "C," "D," "E"). Hunter's Farm, near Belmont and near Norfolk, September 26. Expedition to Belmont November 6-7. Battle of Belmont November 7. Expedition to Milford December 15-19. Milford December 18. Charlestown January 8, 1862. Operations against New Madrid and Island No. 10 February 28-April 8. Sykestown March 1. Actions at New Madrid March 13-14. Action and capture at Tiptonville April 8. Expedition to Fort Pillow, Tenn., April 13-17. Moved to Hamburg Landing, Tenn., April 17-23. Advance on and siege of Corinth, Miss., April 29-May 30. Action at Farmington May 3. Reconnoissance toward Corinth May 8. Action at Farmington May 9. Pursuit to Booneville May 31-June 12. At Corinth till July 20. March to Tuscumbia, Ala., July 20. Guard Memphis & Charleston R. R. in Alabama till August 26. March to Nashville, Tenn., August 26-September 12. Siege of Nashville, Tenn., September 12-November 6. Repulse of Forest's attack on Edgefield November 5. Duty at Nashville till December 26. Advance on Murfreesboro, Tenn., December 26-30. Battle of Stone's River, December 30-31, 1862, and January 1-3, 1863. Duty at Murfreesboro till June. Expedition to Columbia March 4-14. Middle Tennessee (or Tullahoma) Campaign June 24-July 7. Occupation of Middle Tennessee till August 16. Passage of Cumberland Mountains and Tennessee River and Chickamauga Campaign August 16-September 22. Battle of Chickamauga September 19-20. Siege of Chattanooga September 24-November 23. Battles of Chattanooga November 23-25. Orchard Knob November 23-24. Mission Ridge November 25. March to relief of Knoxville November 28-December 8. Operations in East Tennessee till February, 1864. Operations about Dandridge January 16-17, 1864. Veterans on furlough February 10 to March 30. At Cleveland, Tenn., till May. Atlanta (Ga.) Campaign May to July. Demonstrations on Rocky Faced Ridge May 8-11. Buzzard's Roost Gap May 8-9. Battle of Resaca May 14-15. Adairsville May 17. Near Kingston May 18-19. Near Cassville May 19. Advance on Dallas May 22-25. Operations on line of Pumpkin Vine Creek and battles about Dallas, New Hope Church and Allatoona Hills May 25-June 5. Operations about Marietta and against Kenesaw Mountain June 10-July 2. Pine Hill June 11-14. Lost Mountain June 15-17. Assault on Kenesaw June 27.
Mustered out July 7, 1864, expiration of term. Veterans and Recruits transferred to 42nd Illinois Infantry.
Regiment lost during service 2 Officers and 145 Enlisted men killed and mortally wounded, and 2 Officers and 101 Enlisted men by disease. Total 250.